Publications by authors named "A J Thaker"

Purpose: Increasing CT capacity to keep pace with rising ED demand is critical. The conventional process has inherent drawbacks. We evaluated an off-console automated AI enhanced workflow which moves all final series creation off-console.

View Article and Find Full Text PDF

Altered mental status (AMS) and coma are terms used to describe disorders of arousal and content of consciousness. AMS may account for up to 4% to 10% of chief complaints in the emergency department setting and is a common accompanying symptom for other presentations. AMS is not a diagnosis, but rather a term for symptoms of acute or chronic disordered mentation, including confusion, disorientation, lethargy, drowsiness, somnolence, unresponsiveness, agitation, altered behavior, inattention, hallucinations, delusions, and psychosis.

View Article and Find Full Text PDF

Background And Purpose: Brain atrophy occurs in the late stage of dementia, yet structural MRI is widely used in the work-up. Atrophy patterns can suggest a diagnosis of Alzheimer disease (AD) or frontotemporal dementia (FTD) but are difficult to assess visually. We hypothesized that the availability of a quantitative volumetric brain MRI report would increase neuroradiologists' accuracy in diagnosing AD, FTD, or healthy controls compared with visual assessment.

View Article and Find Full Text PDF

Cognitive deficits are long-lasting consequences of drug use, yet the convergent mechanism by which classes of drugs with different pharmacological properties cause similar deficits is unclear. We find that both phencyclidine and methamphetamine, despite differing in their targets in the brain, cause the same glutamatergic neurons in the medial prefrontal cortex of male mice to gain a GABAergic phenotype and decrease expression of their glutamatergic phenotype. Suppressing drug-induced gain of GABA with RNA-interference prevents appearance of memory deficits.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the link between plasma glial fibrillary acidic protein (GFAP) and amyloid levels in relation to cognitive outcomes, focusing on the fornix structure in individuals with Alzheimer's disease (AD).
  • Researchers assessed plasma GFAP and amyloid-β42 levels in a cohort of 99 older adults and used advanced imaging techniques to evaluate the fornix, a brain structure important for memory.
  • Results showed that higher plasma GFAP levels correlated with microstructural changes in the fornix, which in turn mediated the relationship between GFAP and verbal memory performance, particularly in individuals with low amyloid levels.
View Article and Find Full Text PDF