Publications by authors named "A J Silvestri"
Background: Cystic echinococcosis (CE) is a significant public health issue, primarily affecting the liver. While several management strategies exist, there is a lack of predictive tools to guide surgical decisions for hepatic CE. This study aimed to develop predictive models to support surgical decision-making in hepatic CE, enhancing the precision of patient allocation to surgical or non-surgical management pathways.
View Article and Find Full Text PDFAim Of The Study: This real-life study is designed to investigate the short and long-term efficacy and safety of teduglutide (TED) and its effects on the quality of life (QoL) in a cohort of adult, stable patients with short bowel syndrome and chronic intestinal failure receiving long-term parenteral support (PS).
Patient And Methods: A prospective, single-center study was conducted for individuals who began to take TED between March 2017 and August 2023.
Results: Ten patients were included in the analysis, among whom the median duration of TED administration was 48 (range, 12-71) months.
Article Synopsis
- ! Antibiotics are given to 20%-30% of pregnant women, yet their impact on newborn immune development is not well understood, leading to increased susceptibility to sepsis in offspring of treated mothers.
- ! Newborn mice from antibiotic-treated mothers showed lower levels of immunoglobulin A (IgA) in breast milk and feces, leading to a weakened gut immune response and increased risks of gut bacteria entering the bloodstream.
- ! Restoring IgA production through treatments or using breast milk from untreated mothers improved immune profiles and offered protection against sepsis in pups, emphasizing the importance of breastfeeding in mitigating antibiotic effects.
Cross-kingdom RNA interference (ckRNAi) is a mechanism of interspecies communication where small RNAs (sRNAs) are transported from one organism to another; these sRNAs silence target genes in trans by loading into host AGO proteins. In this work, we investigated the occurrence of ckRNAi in Arbuscular Mycorrhizal Symbiosis (AMS). We used an in silico prediction analysis to identify a sRNA (Rir2216) from the AM fungus Rhizophagus irregularis and its putative plant gene target, the Medicago truncatula MtWRKY69 transcription factor.
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