Publications by authors named "A J Seidman"
Article Synopsis
- * Of the 269 patients with RD, 64% were still HER2(+) while 36% had lost HER2 positivity; both subgroups had similar rates of invasive breast cancer recurrence and brain metastasis events during a 24-month follow-up.
- * Overall, higher IDFS (invasive disease-free survival) events were observed in patients with RD compared to those who achieved a pathologic complete response (pCR), indicating that further effective treatment strategies are needed to reduce the
Article Synopsis
- CDK4/6 inhibitors (CDK4/6i) are key 1st line treatments for HR+HER2- metastatic breast cancer, but their effect on brain metastases (BM) is not fully understood.
- A study evaluated 662 patients—363 who received CDK4/6i and 299 who did not—comparing their progression-free survival (CNS PFS) and overall survival (OS) after BM diagnosis.
- Results showed that patients who received CDK4/6i after BM had better CNS PFS and OS than those who received it before, suggesting prior exposure may create resistance, indicating the need for better patient selection strategies.
Aneurysmal bone cysts (ABCs) are rare benign bone lesions with a predilection for the metaphysis of long bones. They are often cystic, expansive, and osteolytic and may result in bony deformity. In general, there remains debate about optimal treatment for ABCs; however, the mainstay typically consists of a combination of curettage, bone grafting, and considering the need for internal fixation and osteotomies.
View Article and Find Full Text PDFIntroduction: During the COVID-19 pandemic, first responders were identified as a high-risk group for developing symptoms of post-traumatic stress disorder (PTSD) and depression, which are commonly associated with negative thoughts about oneself. This may pose risk to perceptions of work self-efficacy, an integral component of employee well-being and occupational functioning. In line with the Job Demands-Resources Model (Demerouti et al.
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