Evaluating the effectiveness of community-informed resource dissemination at increasing knowledge and testing rates among private well water owners in a statewide population.

Background: Threats to groundwater quality pose health risks to private well owners. Knowledge gaps are the main reason for low testing rates. Yet, few studies have examined the extent to which community-informed resource distribution increases knowledge and promotes private well testing.

Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF Syndrome.

Signal transduction downstream of activating stimuli controls CD8+ T cell biology, however these external inputs can become uncoupled from transcriptional regulation in Primary Immune Regulatory Disorders (PIRDs). Gain-of-function (GOF) variants in STAT3 amplify cytokine signaling and cause a severe PIRD characterized by early onset autoimmunity, lymphoproliferation, recurrent infections, and immune dysregulation. In both primary human and mouse models of STAT3 GOF, CD8+ T cells have been implicated as pathogenic drivers of autoimmunity.

Psychosocial effects of a humanoid robot on informal caregivers of people with dementia: A randomised controlled trial with nested interviews.

Background: Dementia rates are rising globally, impacting healthcare systems and society. The care of people with dementia is largely provided by informal caregivers (e.g.

Innovative transgenic zebrafish biosensor for heavy metal detection.

Heavy metal contamination is an urgent environmental issue that poses a significant threat to human health and the ecosystem. To mitigate the adverse impacts of heavy metal pollution, the aim of this research was to develop genetically engineered zebrafish as biosensors, which offer a promising alternative for detecting heavy metal exposure, specifically Cd⁺ and Zn⁺. A novel heavy metal-sensitive gene construct metallothionine 2 promoter with DsRed reporter gene (mt2-DsRed2) was synthesized and integrated into zebrafish embryos using a Tol2 transposon transposase system with the transgenic zebrafish line subjected to biosensing applications for Cd and Zn.

The Use of Arts-Based Methods to Enhance Patient Engagement in Health Research.

Introduction: Patient and care partner engagement in research (PER) is important in generating knowledge to improve healthcare. Arts-based methods (ABM) use art in the research process to share aesthetic knowledge, which is knowledge that may be too complex to share only verbally. Together, PER and ABM are potentially synergistic, as both are participatory, problem-focused, dialogic, and collaborative; yet little is known of the utility of ABM for PER.