Investigating protein degradability through site-specific ubiquitin ligase recruitment.

We report targeted protein degradation through the site-specific recruitment of native ubiquitin ligases to a protein of interest conjugation of E3 ligase ligands. Direct comparison of degradation ability of proteins displaying the corresponding bioconjugation handle at different regions of protein surfaces was explored. We demonstrate the benefit of proximal lysine residues and investigate flexibility in linker length for the design of optimal degraders.

Hospitals Did Not Increase Acute Occupational Therapy Provision Despite Positive Associations With Hospital Performance Under Medicare's Comprehensive Care for Joint Replacement Program.

Importance: Medicare's Comprehensive Care for Joint Replacement (CJR) program rewards hospitals for reducing total Medicare spending. Despite the benefits of occupational therapy (OT) for patient outcomes and spending, little is known about how CJR affects hospital provision of acute occupational OT services.

Objective: Determine whether CJR changed acute OT provision and whether higher acute OT provision was associated with CJR rewards.

"Busting the hidden curriculum" a realist and innovative perspective to foster professional behaviors.

Contemporary health professions education has long delineated the desired attributes of medical professionalism in the form of standard curricula and their role in forming professional behaviors (PBs) among aspiring doctors. However, existing research has shown the contradictory and powerful role of hidden curriculum (HC) in negatively influencing medical students' PBs through unspoken or implicit academic, cultural, or social standards and practices. These contrasting messages of formal curricula and HC lead to discordance and incongruence in future healthcare professionals developing professional identity formation.

Improving meaningful activity and meaningful engagement for residents in long-term care settings.

During the coronavirus disease 2019 (COVID-19) pandemic, restrictions were placed on social contacts and group activities in long-term care settings. Evidence has suggested that social isolation can lead to the onset of health issues including depression and cognitive decline in older people. This article details a quality improvement project undertaken by the managers of nine long-term care settings in Northern Ireland that aimed to enhance meaningful activity and meaningful engagement for residents following the easing of COVID-19 restrictions.

Plant-Based Diets and Their Associations with Physical Performance in the Baltimore Longitudinal Study of Aging.

Background: Plant-based diets are associated with various health benefits; however, their impact on physical performance in aging populations remains unclear.

Objectives: To investigate the associations between adherence to plant-based diets and physical performance, focusing on their potential protective effects against age-related declines in function.

Methods: Data were obtained from men and women aged 40 years or older in the Baltimore Longitudinal Study of Aging (BLSA) (mean ± SD age: 68 ± 13 years at the first dietary visit; n = 1389).