Publications by authors named "A J Ratcliffe"
Background: In the UK, approximately 70% of surgical procedures are undertaken as day-cases. Little information exists about recovery from day-case surgery, yet international data highlights patients are at risk of developing significant longer-term health problems including chronic post-surgical pain and persistent postoperative opioid use. The Patient-reported Outcomes, Postoperative Pain and pain relief after daY case surgery (POPPY) study was a national prospective multicentre observational study, measuring short- and longer-term patient-reported outcomes, postoperative pain and pain relief after day-case surgery.
View Article and Find Full Text PDFBackground: Awareness of paediatric-specific predictors of damage in Childhood-lupus is needed to inform mitigation measures.
Objectives: To ascertain how clinical and demographic variables correlate with damage accrual and identify predictors of damage.
Methods: Analysis included UK JSLE Cohort Study participants.
Article Synopsis
- Developing advanced cell therapy products involves defining key concepts like mechanism of action (MOA), potency, and efficacy, which can be challenging but is crucial for success.
- The text introduces a logical framework that aligns with regulatory guidelines and draws on insights from 27 FDA-approved cell therapy products to better understand these concepts.
- It highlights the complexity of correlating potency test results with clinical outcomes, discusses common misconceptions, and emphasizes the need for effective communication among developers throughout the product development process.
Targeted temperature management in patients with intracerebral haemorrhage, subarachnoid haemorrhage, or acute ischaemic stroke: updated consensus guideline recommendations by the Neuroprotective Therapy Consensus Review (NTCR) group.
Br J Anaesth
August 2023
Background: There is a lack of consistent, evidence-based guidelines for the management of patients with fever after brain injury. The aim was to update previously published consensus recommendations on targeted temperature management after intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and acute ischaemic stroke in patients who require admission to critical care.
Methods: A modified Delphi consensus, the Neuroprotective Therapy Consensus Review (NTCR), included 19 international neuro-intensive care experts with a subspecialty interest in the acute management of intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and acute ischaemic stroke.