Bloodstream Infections in Critical Care Units in England, April 2017 to March 2023: Results from the First Six Years of a National Surveillance Programme.

Background: Patients in critical care units (CCUs) are at an increased risk of bloodstream infections (BSIs), which can be associated with central vascular catheters (CVCs). This study describes BSIs, CVC-BSIs, organism distribution, percentage of antimicrobial resistant (AMR) organisms, and case fatality rates (CFRs) over the first six years of a voluntary national CCU surveillance programme in England.

Methods: Surveillance data on BSIs, CVCs, and bed-days between 04/2017 and 03/2023 for adult CCUs were linked to mortality and AMR data, and crude rates were calculated.

A Mixed Methods Study of Medication Adherence in Adults with Neurofibromatosis Type 1 (NF1) on a Clinical Trial of Selumetinib.

Background: Oral therapeutic options for plexiform neurofibromas (PNs) in individuals with neurofibromatosis type 1 (NF1) are receiving attention in clinical research. The MEK inhibitor (MEKi) Selumetinib is FDA-approved in children ages 2+ years with inoperable PNs, and shows activity in adults. Prolonged therapy with selumetinib is necessary to maintain tumor reduction.

Virginia Memory Project: Using the Healthy Brain Initiative Roadmap to design a statewide dementia registry.

Introduction: The Virginia Memory Project (VMP) is a statewide epidemiological registry for Alzheimer's disease and related disorders (ADRD) and other neurodegenerative conditions. It aims to support dementia research, policy, and care by leveraging the Centers for Disease Control (CDC) Healthy Brain Initiative (HBI) Roadmap.

Methods: To capture comprehensive data, the VMP integrates self-enrollment and automatic enrollment using Virginia's All-Payer Claims Database (APCD).

Point-of-care platform integrated with deep-learning, convolutional neural network algorithms effectively evaluates canine and feline peripheral blood smears.

Objective: To perform a diagnostic assessment of a point-of-care veterinary multiuse platform integrated with a model comprised of deep-learning, convolutional neural network algorithms for evaluating canine/feline peripheral blood smears compared to board-certified clinical pathologists (CPs).

Methods: This study had a blinded, randomized, incomplete block design, and results were compared between CPs and algorithms. Blood smears from convenience samples from veterinary diagnostic reference laboratories from October to December 2021 were used.

Financial hardship and caregiver and child mental health during the 3 years of the COVID-19 pandemic in Australia.

Household income and caregiver mental health are important drivers of children's health and development. The COVID-19 pandemic created huge economic and mental health disruptions. This study examines financial hardship and its relationship with caregiver and child mental health using Australia's only representative data spanning three years of the pandemic.