Publications by authors named "A J Ploeg"
Article Synopsis
- - Root-knot nematodes were identified as the likely cause of serious decline in creeping bentgrass putting greens at a golf course in Indian Wells, California, showing symptoms like yellowing and stunted growth.
- - Morphological and genetic analysis confirmed the presence of the nematodes, with greenhouse trials revealing that many monocot plants could host them, but dicots did not support reproduction.
- - Temperature studies showed that the nematode's life cycle thrives between 17-35 °C, but in greenhouse conditions, even high levels of nematode presence did not significantly harm the bentgrass, suggesting other factors may be involved in the putting greens' damage.
Article Synopsis
- In three clinical trials involving 142 participants with Pompe disease, 17 were deemed suitable for home infusion of avalglucosidase alfa, receiving a total of 419 supervised infusions.
- The majority of participants with late-onset Pompe disease (LOPD) experienced non-serious adverse events, while those with infantile-onset Pompe disease (IOPD) did not report any adverse effects.
- The safety and adverse event rates during home infusion were comparable to those during clinic infusions, indicating that home administration is feasible and safe for stable patients with a prior good infusion history.
California is the primary US producer of processing tomatoes. After decades-long excellent protection against the common tropical spp. , , and (root-knot nematode: RKN) by -resistant tomato cultivars, resistance-breaking RKN populations are spreading throughout the San Joaquin Valley.
View Article and Find Full Text PDFEnzyme replacement therapy (ERT) is the only approved disease-modifying treatment modality for Pompe disease, a rare, inherited metabolic disorder caused by a deficiency in the acid -glucosidase (GAA) enzyme that catabolizes lysosomal glycogen. First-generation recombinant human GAA (rhGAA) ERT (alglucosidase alfa) can slow the progressive muscle degeneration characteristic of the disease. Still, most patients experience diminished efficacy over time, possibly because of poor uptake into target tissues.
View Article and Find Full Text PDFThe European reference network for metabolic diseases (MetabERN) clinical pathway recommendations for Pompe disease (acid maltase deficiency, glycogen storage disease type II).
Orphanet J Rare Dis
November 2024
Article Synopsis
- Clinical pathway recommendations (CPR) provide guidance on managing specific diagnoses, in this case, Pompe disease, a metabolic disorder caused by a deficiency in a specific enzyme.
- The CPR document was created by a working group from MetabERN, which focuses on metabolic diseases, and involved systematic literature searches and quality assessments based on established methodologies.
- This document aims to standardize care for Pompe disease patients by addressing various aspects including pathophysiology, diagnosis, treatment, and follow-up strategies for healthcare providers.