Publications by authors named "A J Pantuck"
Article Synopsis
- The study investigates the use of a radioactive monoclonal antibody, [Zr]Zr-girentuximab, for non-invasive detection of clear-cell renal cell carcinoma in patients with renal masses.
- Conducted across 36 sites in nine countries, the phase 3 trial involved 332 enrolled patients with suspicious renal masses, who received the antibody followed by PET-CT imaging.
- The primary goals of the trial were to assess the sensitivity and specificity of the imaging technique using histopathological confirmation as the standard, with findings from 300 patients eventually analyzed.
Article Synopsis
- MAGE-A is a cancer-associated antigen expressed in various tumors but has limited presence in normal tissues; this study focused on its expression in urinary bladder and lung cancers while evaluating the immune environment.
- The researchers analyzed MAGE-A and PD-L1 levels in tumor samples using immunohistochemistry and RNA sequencing, finding that 57% of samples showed detectable MAGE-A expression, with no significant difference between the two cancer types.
- Treatment with checkpoint inhibitors did not alter MAGE-A expression or other immune markers in urothelial carcinoma, suggesting that previous tumor samples can still be useful for evaluating MAGE-targeted treatments.
ALK-rearranged RCC refractory to several lines of treatment has a durable response when treated with alectinib.
View Article and Find Full Text PDFApproximately 65% of renal cell carcinomas (RCC) are diagnosed at a localized stage. We investigated the chromosome 5q gain impact on disease-free survival (DFS) in RCC patients. Overall, 676 patients with stages 1-2 RCC and having cytogenetic analysis were included.
View Article and Find Full Text PDFBackground: CD70 is commonly overexpressed in renal cell carcinoma and is minimally expressed in normal human tissue, making it a potential therapeutic target for patients with advanced renal cell carcinoma. The expression frequency of CD70 in metastatic renal cell carcinoma is not well established.
Materials And Methods: We assessed CD70 immunohistochemistry in 391 primary renal tumors and 72 metastatic renal cell carcinomas on a tissue microarray including 26 sets of paired primary and metastatic tumors.