Publications by authors named "A J Ouwehand"
Article Synopsis
- 2'-fucosyllactose (2'-FL) in human milk promotes gut health and immune development in infants, while Bi-26™ is a beneficial bacterium found in breastfed infants.
- The study used piglets to test the effects of 2'-FL and Bi-26™ on immune development, with results showing increased levels of certain cytokines in the serum of piglets receiving 2'-FL compared to those that did not.
- Findings suggest that 2'-FL enhances cytokine responses without altering immune cell populations and that Bi-26™ can moderate the pro-inflammatory response in immune cells stimulated by LPS.
The gut microbiome is impacted by certain types of dietary fibre. However, the type, duration and dose needed to elicit gut microbial changes and whether these changes also influence microbial metabolites remain unclear. This study investigated the effects of supplementing healthy participants with two types of non-digestible carbohydrates (resistant starch (RS) and polydextrose (PD)) on the stool microbiota and microbial metabolite concentrations in plasma, stool and urine, as secondary outcomes in the Dietary Intervention Stem Cells and Colorectal Cancer (DISC) Study.
View Article and Find Full Text PDFChitin-glucan (CG) is a new generation of prebiotic. NCFM (NCFM) is a probiotic with the ability to decrease abdominal pain. We evaluate the functional and molecular gastrointestinal responses to a synbiotic administration combining CG and NCFM in a rat model of long-lasting colon hypersensitivity.
View Article and Find Full Text PDFImportance: Probiotic supplementation may improve bowel movements. However, large, properly designed studies are lacking.
Objective: To evaluate the potential benefit of Bifidobacterium animalis subsp lactis HN019 on constipation, expressed as complete spontaneous bowel movements (CSBMs).
Aging has been associated with a changed composition and function of the gut microbiota (GM). Here, we investigate the effects of the multi-strain probiotic HOWARU Restore on GM composition and function in seniors. Ninety-eight healthy adult volunteers aged ≥75 years were enrolled in a randomised, double-blinded intervention (NCT02207140), where they received HOWARU Restore (10 CFU) or the placebo daily for 24 weeks, with 45 volunteers from each group completing the intervention.
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