Weapon use during the index offense: a study among forensic psychiatry patients in Ontario, Canada.

Background: Understanding the nature and circumstances around the use of weapons to perpetrate an offense among individuals with mental illness is crucial for evidence-informed policies and actions. However, little is known about the prevalence and factors associated with weapon use during index offenses among patients in the forensic system. Therefore, the present study was designed to address this gap and determine the prevalence and the patient and victim characteristics associated with weapon use during the index offense in a Canadian province.

Characterizing the relationship between psychosis and violence in the forensic psychiatric population: a systematic review.

Objective: The relationship between psychosis and violence is often construed focusing on a narrow panel of factors; however, recent evidence suggests violence might be linked to a complex interplay of biopsychosocial factors among forensic psychiatric patients with psychosis (FPPP). This review describes violence incidents in FPPP, the factors associated with violence, and relevant implications.

Methods: This review was conducted following the preferred reporting items for systematic reviews and meta-analyses guideline.

Mentorship in medical education: reflections on the importance of both unofficial and official mentorship programs.

Mentorship, consisting of its official and unofficial forms, transforms medical trainees into competent and well-rounded physicians. In this commentary, we reflected on existing mentorship programs at the McMaster School of Medicine, highlighted lessons from a new peer-based mentorship program, and revisited the benefits of integrating diverse mentorship styles to enhance medical education.

Long-Lasting, Fine-Tuned Anti-Tumor Activity of Recombinant Vaccine Is Controlled by Pyroptosis and Necroptosis Regulatory and Effector Molecules.

One of the main objectives of developing new anti-cancer vaccine strategies is to effectively induce CD8+ T cell-mediated anti-tumor immunity. Live recombinant vectors, notably , have been shown to elicit a robust in vivo CD8+ T-cell response in preclinical settings. Significantly, it has been demonstrated that induces inflammatory/immunogenic cell death mechanisms such as pyroptosis and necroptosis in immune cells that favorably control immunological responses.