The potential role of mangiferin in cancer treatment through its immunomodulatory, anti-angiogenic, apoptopic, and gene regulatory effects.

Mangiferin (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside) is a natural bioactive xanthonoid that can be found in many plant species, among which the mango tree (Mangifera indica L), a plant widely used in the traditional medicinal, is one of its primary sources. The use of mangiferin for cancer treatment has attracted the attention of research groups around the World. Single administration of mangiferin or in combination with known anticancer chemicals has shown the potential benefits of this molecule in lung, brain, breast, cervix, and prostate cancers, and leukemia.

Mango Polyphenols and Its Protective Effects on Diseases Associated to Oxidative Stress.

Biological effects of natural polyphenols from mango and their potential impact on human health have become of increasing interest. The occurrence of glycosilated molecules, such as mangiferin (C2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone), main component of the mango polyphenolic fraction, and benzophenones, flavonoids (catechin and epicatechin), phenolic acids (benzoic and gallic), and a wide range of derivatives, provide a high chemical complexity. In this review, the potential impact of mango polyphenols and its protective effects on diseases associated to oxidative stress is discussed.

In vivo acute toxicological studies of an antioxidant extract from Mangifera indica L. (Vimang).

Mango (Mangifera indica L.) stem bark aqueous extract (MSBE) is a natural product with antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Its formulations (e.

Lack of in vivo embryotoxic and genotoxic activities of orally administered stem bark aqueous extract of Mangifera indica L. (Vimang).

Mango (Mangifera indica L.) stem bark aqueous extract (MSBE) is a new natural product with antioxidant, anti-inflammatory and immunomodulatory effects known by the brand name of its formulations as Vimang. Previously, the oral toxicity studies of the extract showed a low toxicity potential up to 2000 mg/kg.

The paradox of natural products as pharmaceuticals. Experimental evidences of a mango stem bark extract.

Recent findings regarding basic, pre-clinical and clinical studies on a mango stem bark extract (MSBE) developed in Cuba (Vimang) on an industrial scale are summarized. Ethnomedical studies, extract reproducibility, biological effects and clinical evaluations in terms of patient quality of life are described as experimental evidences to support the statement that natural products, even being a mixture of compounds, could be as effective as "monoceuticals" for medical uses. Discussion about the use of "monoceuticals" versus "natureceuticals" in health care and medicine is based on effectiveness and availability, taking Vimang as an example of a natural product with supported scientific evidence to be used as antioxidant, analgesic, anti-inflammatory and immunomodulator.