Publications by authors named "A J Noyce"
Depression and dementia: interrogating the causality of the relationship.
J Neurol Neurosurg Psychiatry
January 2025
Background: Depression is often cited as a major modifiable risk factor for dementia, though the relative contributions of a true causal relationship, reverse causality and confounding factors remain unclear. This study applied a subset of the Bradford Hill criteria for causation to depression and dementia including strength of effect, specificity, temporality, biological gradient and coherence.
Methods: A total of 491 557 participants in UK Biobank aged between 40 and 69 at enrolment and followed up for a mean duration of 12.
Background: Dual-task (DT) performance is impaired in Parkinson's disease (PD), contributing to bradykinesia, postural instability, freezing of gait, and falls. Tactile cueing, including vibrotactile stimulation, has been suggested to improve DT performance in PD.
Research Question: Does tactile cueing affect DT performance in PD, specifically measured by dual-task cost (DTC)?
Methods: A systematic review was conducted in PubMed and EMBASE up to October 30, 2023, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.
Article Synopsis
- * Researchers used genome-wide association studies (GWAS) to identify a negative correlation between olfactory ability and PD at a genetic level, finding specific genetic locations tied to both traits.
- * The study suggests a strong causal relationship where poorer sense of smell may indicate a higher risk for PD, rather than PD itself causing diminished olfactory function.
The age-standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes the need to identify modifiable risk factors of PD, which could form a logical entry point for the prevention of PD. The World Health Organization (WHO) has recommended reducing exposure to specific environmental factors that have been reported to be associated with PD, in particular pesticides, trichloroethylene (TCE), and air pollution.
View Article and Find Full Text PDFBackground: Preferences for risk disclosure in population-based studies assessing Parkinson's disease (PD) risk have not been assessed so far.
Objectives: To examine preferences for risk disclosure in a subset of the European Healthy Brain Aging (HeBA) multicenter study.
Methods: After a remote PD risk assessment, a structured pilot-questionnaire on risk disclosure was first presented to participants (≥50 years, without neurodegenerative diseases) during in-person visits at the Innsbruck study site.