Publications by authors named "A J Northrop"
Article Synopsis
- Long-term exposure to PM2.5, especially from wildfires, has been linked to an increased risk of developing dementia, although the specific impact of wildfire-generated PM2.5 is not well understood.
- The study analyzed electronic health records from over 1.2 million Kaiser Permanente members aged 60 and older in Southern California from 2008 to 2019 to investigate this association.
- It used a statistical approach to evaluate the relationship between three-year averages of wildfire and nonwildfire PM2.5 exposure and the incidence of dementia, while controlling for various demographic and socioeconomic factors.
Article Synopsis
- Misfolded tau proteins, associated with neurodegeneration in Alzheimer's and frontotemporal dementia, spread between cells but the exact release mechanisms are not well understood.
- Research shows that the neuronal gene Arc is crucial for packing tau into extracellular vesicles (EVs) that can elicit tau pathology-seeding in the brain.
- In experiments, Arc knockout mice produced fewer tau-containing EVs and demonstrated a significant reduction in intercellular tau transmission, indicating that Arc plays a vital role in both tau release and its spread across neurons.
The maximum galloping speeds of racehorses during a race are influenced by the functional performance of the ground ('going') amongst other factors. For turf racecourses in Britain, the ground is descriptively classified and numerically quantified on the morning of a race meeting by the clerk of the course and subsequently published to assist decision making. Importantly, this includes deciding whether a horse should or should not run.
View Article and Find Full Text PDFObjectives: We describe the development and implementation of a system for monitoring patient-reported adverse events and quality of life using electronic Patient Reported Outcome (ePRO) instruments in the I-SPY2 Trial, a phase II clinical trial for locally advanced breast cancer. We describe the administration of technological, workflow, and behavior change interventions and their associated impact on questionnaire completion.
Materials And Methods: Using the OpenClinica electronic data capture system, we developed rules-based logic to build automated ePRO surveys, customized to the I-SPY2 treatment schedule.
Children's risk of exposure to carbon monoxide (CO) increases after disasters, likely due to improper generator use during power outages. Here, we evaluate the impact of outages on children's CO-related emergency department (ED) visits in New York State (NYS). We leveraged power outage data spanning 2017-2020 from the NYS Department of Public Service for 1,865 power operating localities (i.
View Article and Find Full Text PDF