Publications by authors named "A J Nederveen"

Repeated muscle micro-trauma may cause severe muscle damage. Diffusion tensor imaging (DTI) exhibits sensitivity to microstructural changes in skeletal muscle. We hypothesize that longer diffusion times enhance sensitivity to micro-trauma and that membrane permeability increases with micro-trauma.

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Objectives: The common surgical treatment in patients with obstructive hypertrophic cardiomyopathy is septal myectomy. This involves resection of a segment of the myocardial septum and can be performed with and without concomitant anterior mitral valve leaflet extension (AMVLE). While both approaches have satisfying clinical outcomes, there is a lack of data regarding the added value of concomitant AMVLE.

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Article Synopsis
  • Silent cerebral infarcts (SCIs) are common in patients with severe forms of sickle cell disease (SCD) and thalassemia, although the underlying causes are not fully understood.
  • This study compared cerebral blood flow, oxygen metabolism, and SCI lesions in severe and mild SCD patients, thalassemia patients, and healthy controls before and after a vasodilatory challenge.
  • Findings showed that while severe SCD and thalassemia patients had higher blood flow, their oxygen consumption was lower; this suggests that anemia rather than cerebral blood flow may play a key role in the development of SCIs, especially in milder forms of SCD.
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The rapid growth of mobile phone usage and its use of radiofrequency electromagnetic fields (RF-EMF) have raised concerns about potential health risks. Researchers have conducted studies to examine the effects of RF-EMF on the brain using electroencephalography (EEG). We conducted a systematic quality assessment and meta-analysis of published research in this field to establish high-quality studies as references for future protocols.

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The conventional gradient-echo steady-state signal model is the basis of various spoiled gradient-echo (SPGR) based quantitative MRI models, including variable flip angle (VFA) MRI and dynamic contrast-enhanced MRI (DCE). However, including preparation pulses, such as fat suppression or saturation bands, disrupts the steady-state and leads to a bias in T and DCE parameter estimates. This work introduces a signal model that improves the accuracy of VFA T-mapping and DCE for interrupted spoiled gradient-echo (I-SPGR) acquisitions.

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