Public Health.

Background: The higher prevalence and incidence of later life dementia among older Black Americans compared to older White Americans is incompletely understood and understudied. HATS is designed as a companion to the Mayo Clinic Study of Aging (MCSA) with a focus on identification of modifiable cardiovascular contributions to brain health among Black older adults living in urban areas in the upper Midwest.

Method: HATS is enrolling 300 U.

Public Health.

Background: Although the importance of body weight in later life for brain health has been established, less is known about body shape and composition. This study aims to examine their associations with dementia and cognitive changes in older adults.

Method: Data were obtained from over 17,000 community-dwelling individuals aged 65-98 years, recruited in Australia and the US.

Developing Topics.

Background: Evidence is growing supporting sex- and gender- specific differences in risk factors for dementia, and varying pathways to diagnosis. Recognized sex differences in brain structure and function could contribute to differences in plasma biomarker concentrations and in susceptibility to brain pathologies. Furthermore, differences in comorbidities between males and females (e.

Developing Topics.

Background: Blood-based biomarkers of Alzheimer's Disease (AD) are ideally suited for use at the population level for screening, diagnosis, and for serial assessments to track disease progression. However, a number of critical knowledge gaps remain. Importantly, 1) these biomarkers have not been sufficiently examined in longitudinal studies of older community-based populations without diagnosed dementia; and 2) it is unclear how participant characteristics such as sociodemographic characteristics and chronic conditions affect the clinical interpretation of these biomarkers.

Influence of cadence manipulation on running biomechanics in high school cross-country runners.

Increasing cadence is an intervention to reduce injury risk for adolescent long-distance runners. It is unknown how adolescents respond biomechanically when running with a higher than preferred cadence. We examined the influence of increasing cadence on peak joint angles, moments and powers, and ground reaction forces in long-distance runners.