Development and Characterization of a High-Affinity Selective Galectin-3 Mouse Tool Compound in Mouse Models of Cancer.

The interest in galectin-3 as a drug target in the cancer and fibrosis space has grown during the past few years with several new classes of compounds being developed. The first orally available galectin-3 inhibitor, (h-galectin-3 K = 0.025 μM), is currently in phase 2 clinical trials.

Diagnostic development and needs for laser driven MeV x-ray radiography.

Laser-driven MeV x-ray radiography of dynamic, dense objects demands a small, high flux source of energetic x-rays to generate an image with sufficient quality. Understanding the multi-MeV x-ray spectrum underscores the ability to extrapolate from the current laser sources to new future lasers that might deploy this radiography modality. Here, we present a small study of the existing x-ray diagnostics and techniques.