Publications by authors named "A J M Ferreri"
Ultrasound-guided Transversus Abdominis Plane Block (UG-TAPB) reduces post-operative pain better than i.v. painkillers in patients operated with laparoscopic surgery.
View Article and Find Full Text PDFSevere ICANS after CAR T-cell therapy and assessment of prevention with levetiracetam for seizure prophylaxis following CAR T-cell for DLBCL & PMBCL in Europe: a survey on behalf of the Cellular Therapy & Immunobiology Working Party (CTIWP) of the EBMT.
Piera Angelillo Ana Alarcon Tomas Edoardo Campodonico Urban Novak Ludovic Gabellier Andres J M Ferreri
Bone Marrow Transplant
October 2024
Given the significant limitations of available literature, central nervous system (CNS) prophylaxis in large B-cell lymphomas remains debatable. Wilson and colleagues provide cautious recommendations, on a case-by-case basis, useful to guide discussion with individual patient. In daily practice, CNS relapse risk, prophylaxis safety and prognosis of CNS recurrence must be considered.
View Article and Find Full Text PDFArticle Synopsis
- The IELSG37 trial investigated whether patients with primary mediastinal B-cell lymphoma (PMBCL) who have a complete metabolic response (CMR) after treatment can safely skip consolidation radiotherapy.
- It was a randomized noninferiority study involving 545 patients, focusing on progression-free survival (PFS) over 30 months, with results showing high PFS rates of 96.2% for observation and 98.5% for radiotherapy.
- The study concluded that avoiding irradiation does not negatively impact survival, highlighting positive outcomes for patients with CMR.
Article Synopsis
- Deficient DNA mismatch repair (dMMR) serves as a biomarker indicating a better response to PD-1 blockade immunotherapy in solid tumors, including diffuse large B-cell lymphoma (DLBCL).
- In a study involving a large cohort of DLBCL patients, genetic dMMR was found infrequently and linked to a more favorable immune microenvironment but did not show a strong prognostic impact.
- Additionally, while phenotypic dMMR was also rare, its presence correlated with increased T cell activity, suggesting that PD-1 T cells may selectively target tumor cell subsets with dMMR, which has implications for the efficacy of immunotherapy in DLBCL.