Effect of deep brain stimulation on nonmotor symptoms in essential tremor.

Objective: Essential tremor (ET) is a prevalent movement disorder that also includes nonmotor symptoms such as anxiety, depression, and cognitive impairment. Deep brain stimulation (DBS) is an established treatment for ET, yet its impact on nonmotor symptoms remains unclear. This study aims to describe neuropsychological outcomes following ventral intermediate nucleus (VIM) DBS in a large cohort of patients with ET and identify factors associated with changes in depression and cognitive function.

Vascularised organoids: Recent advances and applications in cancer research.

Organoids are three-dimensional (3D) cellular models designed to replicate human tissues and organs while preserving their physiological complexity and functionality. Among these, vascularised organoids represent a groundbreaking advancement in 3D tissue engineering, incorporating vascular networks into engineered tissues to more accurately mimic the in vivo tumour microenvironment. These models offer significantly improved physiological relevance compared to conventional two-dimensional cultures or animal models, positioning them as invaluable tools in cancer research.

An Internal Medicine Resident Continuity Clinic at a Federally Qualified Health Center: Structure, Feasibility, and Early Outcomes.

Background: Educational opportunities in federally qualified health centers (FQHCs) are important to develop our physician workforce at FQHCs but are rare in internal medicine (IM) training programs.

Aim: To describe the process, feasibility, and early outcomes of an IM resident continuity clinic at a FQHC.

Setting And Participants: The IM residency is a large academic program.

Self-assembled clusters of magnetically tilted dipoles.

Motivated by the idea of using simple macroscopic examples to illustrate the physics of complex systems, we modify a historic experimental setup in which interacting floating magnets spontaneously self-assemble into ordered clusters. By making the cluster components mechanically stable against their natural tendency to flip and coalesce, we can monitor the torque experienced by individual magnets through the macroscopic tilt angles they acquire when exposed to noncollinear external fields. A mathematical model that reproduces the empirical observations is introduced, enabling us to go beyond the experimental cases considered.

Time-of-flight widefield microscopy.

High-resolution depth imaging is essential in fields such as biological microscopy and material science. Traditional techniques like interferometry and holography often rely on phase stability and coherence, making them susceptible to noise and limiting their effectiveness in low-light conditions. We propose a time-of-flight (ToF) widefield microscopy technique that uses pseudo-thermal light.