Publications by authors named "A J Lotery"
Article Synopsis
- * By analyzing data from the Million Veteran Program and other cohorts, the study identifies 63 genetic loci linked to AMD, including 30 that were previously unknown, highlighting significant differences in risk among various ancestries.
- * The findings reveal that certain genetic risk factors, like those found in the CFH locus, have varying effects based on ancestry, suggesting that targeted therapies could be developed by considering these genetic differences.
Article Synopsis
- Age-related macular degeneration (AMD) is the primary cause of permanent blindness in developed countries, with certain genetic variations in the complement factor I (CFI) gene increasing the risk of developing the disease.
- Research focusing on the Finnish population revealed novel CFI rare variants (RVs) in individuals with dry AMD, highlighting the need to understand how these genetic factors influence disease progression.
- Functional assays showed the G547R variant severely disrupts CFI's regulatory role in the complement system, while another variant, G328R, affects protein production; these findings suggest that certain RVs significantly contribute to AMD risk in this population.
Article Synopsis
- Globally, while people are living longer, many experience a decline in health due to age-related diseases, highlighting the need for better classification systems to address these issues.
- A consensus meeting with 150 experts established criteria for identifying ageing-related pathologies, requiring a 70% agreement for approval among participants.
- The agreed criteria focus on conditions that progress with age, contribute to functional decline, and are backed by human studies, setting a foundation for future classification and staging efforts.
Article Synopsis
- Some patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO) don't respond well to standard anti-VEGF treatments, prompting the need for alternative therapies like faricimab.
- A meeting with UK retina specialists discussed how to identify patients who could benefit from switching treatments and reviewed relevant clinical trial data and real-world experiences.
- The panel emphasized the importance of recognizing suboptimal responses and proposed strategies for integrating faricimab into current treatment plans for patients with a history of anti-VEGF therapy.
Purpose: To report a case of central retinal artery and common carotid artery occlusions following COVID-19 infection in a young female with no other risk factors.
Methods: Retrospective analysis of the medical notes of a patient hospitalized with COVID 19 infection at University Hospital Southampton.
Results: The patient was found to have dural venous sinus thrombosis and an acute infarct within the right parietal lobe.