Publications by authors named "A J Lewy"
Objective: To determine whether there is a correlation between mood and the alignment between the timing of the circadian pacemaker (circadian phase) and the timing of sleep in healthy, euthymic individuals.
Methods: Participants were 25 first-year medical students (25.9 ± 3.
Article Synopsis
- The study aimed to investigate possible circadian or sleep-regulatory dysfunction in sighted individuals with non-24-hour sleep-wake rhythm disorder.
- Researchers assessed three individuals through a range of laboratory and home-based evaluations over several months to analyze their sleep-wake timing and circadian rhythms.
- Findings indicated no signs of circadian dysfunction; instead, their sleep-wake patterns seemed to influence the circadian clock, suggesting that the disorder may be influenced by light exposure or behaviors rather than an inherent biological issue.*
Study Objectives: To assess the interindividual and intraindividual variability in the circadian rhythms of blind individuals with non-24-h disorder and to quantify the influence of environmental time cues in blind subjects lacking entrainment (non-24-h individuals or N-24s).
Design: An observational study of 21 N-24s (11 females and 10 males, age 9-78 years) who kept a sleep/wake schedule of their choosing. Circadian phase was determined using the melatonin onset (MO) from plasma or saliva samples that were collected every 2 weeks.
In the absence of the entraining light-dark cycle, most totally blind humans free-run, albeit with relative coordination to nonphotic zeitgebers. Such blind free-runners (BFRs) often attempt to maintain a 24-h sleep-wake schedule and consequently suffer from recurrent sleep disruption and daytime somnolence. This study was conducted to determine the periods of the free-running melatonin rhythm and of the rest-activity cycle in 16 BFRs.
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