Publications by authors named "A J Lando"
The target of rapamycin (TOR) is a central hub kinase that promotes growth and development in all eukaryote cells. TOR induces protein synthesis through the phosphorylation of the S6 kinase (S6K), which, in turn, phosphorylates ribosomal S6 protein (RPS6) increasing this anabolic process. Therefore, S6K and RPS6 phosphorylation are generally used as readouts of TOR activity.
View Article and Find Full Text PDFCarbohydrates serve crucial functions in most living cells, encompassing structural and metabolic roles. Within the realms of plant and algal biology, carbohydrate biosynthesis and partitioning play pivotal roles in growth, development, stress physiology, and various practical applications. These applications span diverse fields, including the food and feed industry, bioenergetics (biofuels), and environmental management.
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- The review analyzes predictive factors for motor recovery in stroke patients undergoing rehabilitation, focusing on what influences patient responses to treatment.
- Only 6% of the studied research examined these predictive factors, revealing that over 30 hours of therapy can lead to notable clinical improvements, especially through task-oriented approaches.
- Key indicators of recovery included the integrity of the corticospinal tract, preservation of arm function, and certain genetic markers, suggesting that rehabilitation strategies should consider these elements for better outcomes.
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- A systematic evaluation is necessary to understand how different model architectures and training strategies affect the performance of genomics models, prompting the organization of a DREAM Challenge.
- In the challenge, competitors used a vast dataset of yeast DNA sequences and expression levels to train models, with the best models employing various neural network architectures and training approaches.
- The development of the Prix Fixe framework allowed for an in-depth analysis of these models, leading to improved performance, and demonstrating that top models not only excelled on yeast data but also outperformed existing benchmarks in Drosophila and human datasets.
This study provides evidence about the relationship between Target of Rapamycin (TOR) kinase and the signal molecule nitric oxide (NO) in plants. We showed that sucrose (SUC)-mediated TOR activation of root apical meristem (RAM) requires NO and that NO, in turn, participates in the regulation of TOR signaling. Nitric oxide (NO) constitutes a signal molecule that regulates important target proteins related to growth and development and also contributes to metabolic reprogramming that occurs under adverse conditions.
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