Navigating challenges of breast implant rupture in a rugby player: Challenges and risk assessment.

Sports physicians need to be aware of potential complications related to breast implants in athletes. Problems with breast implants can affect an athlete's physical health, overall mental well-being and performance. This case report explores the challenges sports physicians face in diagnosing and managing breast implant ruptures in athletes.

Higher Circulating ACE2 and DPP3 but Reduced ACE and Angiotensinogen in Hyperreninemic Sepsis Patients.

Sepsis and septic shock are global healthcare problems associated with high mortality rates.  Activation of the renin-angiotensin-aldosterone system (RAAS) is an early event in sepsis and elevated renin may be predictive of worse outcomes.  In a subset of sepsis patients enrolled in the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) trial, active renin (median value > 189 pg/mL or 5.

Social network dynamics of tobacco smoking and alcohol use among persons involved with the criminal legal system (PCLS): A modeling study.

Background: Tobacco smoking and alcohol use contribute to a synergy of epidemics (a "syndemic") that disproportionately affects persons involved with the criminal legal system (PCLS) and their social networks. An improved understanding of the complex interrelationships among the factors of the incarceration-tobacco-alcohol syndemic is essential to develop effective reform policies and interventions. However, collecting empirical data on these interrelationships is often hampered due to logistical and ethical challenges.

Potent antitumor activity of a designed interleukin-21 mimic.

Long-standing goals of cancer immunotherapy are to activate cytotoxic antitumor T cells across a broad range of affinities while dampening suppressive regulatory T (Treg) cell responses, but current approaches achieve these goals with limited success. Here, we report a IL-21 mimic, 21h10, designed to have augmented stability and high signaling potency in both humans and mice. In multiple animal models and in human melanoma patient derived organotypic tumor spheroids (PDOTS), 21h10 showed robust antitumor activity.