Bacteria Engineered to Produce Serotonin Modulate Host Intestinal Physiology.

Bacteria in the gastrointestinal tract play a crucial role in intestinal motility, homeostasis, and dysfunction. Unraveling the mechanisms by which microbes impact the host poses many challenges due to the extensive array of metabolites produced or metabolized by bacteria in the gut. Here, we describe the engineering of a gut commensal bacterium, Nissle 1917, to biosynthesize the human metabolite serotonin for examining the effects of microbially produced biogenic amines on host physiology.

Wait, Where's the Flynn Effect on the WAIS-5?

The recent release of the WAIS-5, a decade and a half after its predecessor, the WAIS-IV, raises immediate questions about the Flynn effect (FE). Does the traditional FE of points per decade in the U.S.

Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut.

While fecal microbiota transplantation (FMT) has been shown to be effective in reversing gut dysbiosis, we lack an understanding of the fundamental processes underlying microbial engraftment in the mammalian gut. Here, we explored a murine gut colonization model leveraging natural inter-individual variations in gut microbiomes to elucidate the spatiotemporal dynamics of FMT. We identified a natural "super-donor" consortium that robustly engrafts into diverse recipients and resists reciprocal colonization.

Serial OCT Imaging of Spontaneous Closure of a Pediatric Traumatic Macular Hole.

To describe a case of spontaneous closure of a pediatric traumatic macular hole (MH) using serial optical coherence tomography (OCT) imaging. A single case was evaluated. An 8-year-old girl developed a full-thickness MH in the right eye after sustaining blunt trauma from a bungee cord.