Long-Term Survival After Curative Resection of a Primary Clear Cell Carcinoma of the Pancreas: A Report of a Case.

Clear cell pancreatic carcinoma, as a primary lesion, represents a rare malignant entity with very few references. As for the incidence, the clinical characteristics and the prognosis are still to be defined. Here, we present the case of a 73-year-old female who presented with epigastric pain radiating to the back, anorexia, and dyspepsia.

Intestinal Obstruction Due to Ingested Olive Pits.

Intestinal obstruction after ingestion of foreign bodies is a rare condition. A wide variety of ingested foreign bodies has been reported as a cause of mechanical small bowel obstruction, with ingested fruit pits being rarely reported as causes of intestinal obstruction. Here, we report the case of a 70-year-old female diagnosed with intestinal obstruction due to swallowed olive pits tightly impacted in the distal ileum.

Inflammation-attenuating effect of carbon dioxide versus room-air environment in a rat laparotomy model.

Background: The mechanism by which laparoscopic operations induce lower post-operative inflammatory response compared to open surgery was investigated with regard to the effect of the type of gas environment.

Methods: Rats were subjected to midline laparotomy at either CO (group CO) or room-air environment (group Air) or to anesthesia only (group Control) under atmospheric pressure conditions. At various timepoints after surgery (1, 3, 6, 24, or 48 h), the expression of inflammation biomarkers interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), and nuclear factor-κΒ (NFκΒ) were assessed immunohistochemically in tissue samples excised from the liver, intestine, and kidneys, accompanied by histopathologic analysis, and their levels were measured by ELISA in blood samples.

Prognostic significance of BRCA1 and BRCA2 methylation status in circulating cell-free DNA of Pancreatic Cancer patients.

Pancreatic cancer is the most fatal cancer type in the world. Its high mortality is mostly correlated to the absence of symptoms and the difficulty in early diagnosis, which in the majority of the cases occurs when the disease has already spread metastasis. Nowadays, tests that could predict early diagnosis are not available yet and the number of prognostic tests is limited.

Gut Barrier Disruption Secondary to Radiofrequency-Assisted Liver Parenchyma Resection in a Porcine Model.

Background: Radiofrequency-assisted liver resection (RF-LR) techniques minimize intraoperative blood loss, while avoiding the Pringle maneuver. Both surgical excision and radiofrequency ablation of liver parenchyma compromise gut barrier function with subsequent bacterial translocation. The present study sought to investigate in a porcine model the impact of two RF-LR techniques on the integrity and inflammatory response of the gut barrier.