Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases.

At the heart of many nucleoside triphosphatases is a conserved phosphate-binding sequence motif. A current model of early enzyme evolution proposes that this 6-8 residue motif could have sparked the emergence of the very first nucleoside triphosphatases - a striking example of evolutionary continuity from simple beginnings, if true. To test this provocative model, seven disembodied Walker A-derived peptides were extensively computationally characterized.

Biaryl Phosphates and Phosphonates as Selective Inhibitors of the Transcription Factor STAT4.

The transcription factor STAT4 has been implicated in the pathogenesis of autoimmune diseases including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and diabetes mellitus. Here, we report p-biaryl phosphates and phosphonates as the first small-molecule inhibitors of STAT4. The most potent p-biaryl phosphate inhibited the protein-protein interaction domain of STAT4, the SH2 domain, with submicromolar potency (Ki = 0.

Enhancing Knowledge and Confidence in Wilderness Medicine Through Virtual Education: Lessons From a National Boot Camp.

Wilderness medicine (WM) education is an important aspect of training for sports medicine fellows, preparing healthcare providers to address medical challenges in remote and austere environments. It is traditionally taught in immersive, in-person settings. The COVID-19 pandemic prompted a rapid shift toward virtual education platforms, challenging traditional teaching methods.

Barriers to Accessing Care and Support Services for Older Immigrants and Immigrants with Dementia in Finland: Perspectives of Professional Social and Health Care Providers.

Older people's immigration to a different country can place them in a vulnerable situation. Research on the legal rights and access to justice for older immigrants and immigrants with dementia seeking care and support is scarce in Finland. This study addresses this gap in the research and employs semi-structured qualitative interviews with professionals offering services to this target group.

Postglacial Recolonization of the Southern Ocean by Elephant Seals Occurred From Multiple Glacial Refugia.

The Southern Ocean is warming more rapidly than other parts of our planet. How this region's endemic biodiversity will respond to such changes can be illuminated by studying past events through genetic analyses of time-series data sets, including historic and fossil remains. Archaeological and subfossil remains show that the southern elephant seal (Mirounga leonina) was common along the coasts of Australia and New Zealand in the recent past.