Publications by authors named "A J House"

Objective: Tuberous sclerosis complex (TSC) is a monogenetic disorder associated with sustained mechanistic target of rapamycin (mTOR) activation, leading to heterogeneous clinical manifestations. Epilepsy and renal angiomyolipoma are the most important causes of morbidity in adult people with TSC (pwTSC). mTOR is a key player in inflammation, which in turn could influence TSC-related clinical manifestations.

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Objective: To compare preoperative and postoperative cross-sectional areas (CSAs) of the external nares and nasal vestibule on computed tomography (CT) transverse sections in brachycephalic dogs that underwent a vestibuloplasty in combination with either a Trader's technique or vertical wedge resection rhinoplasty.

Methods: Medical records and corresponding preoperative and postoperative head computed tomographic images were reviewed to measure CSA at two defined points on transverse sections of the nasal cavities.

Results: Nine brachycephalic dogs were included for analysis.

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Article Synopsis
  • A 4.5-year-old female spayed mixed breed dog presented with sudden vomiting and abdominal pain after a previous surgery for similar issues, which had no clear cause.
  • A CT scan indicated a mechanical obstruction in the small intestine, leading to further surgery.
  • Surgery revealed strangulation of the jejunum due to a rent from prior surgery, and removing the median ligament resolved the symptoms, highlighting the need to prevent such injuries during abdominal procedures.
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There may be inter-/intra-surgeon variability in the repair of congenital heart defects. The objective was to analyze and visualize inter-/intra-surgeon variability in the level of patch suture lines and in the shape and size of patches developed through surgical simulation for partial anomalous pulmonary venous connection (PAPVC) repair using a patient-specific 3D-printed heart model. A patient with PAPVC and preoperative computed tomography data were selected, and a patient-specific heart model was obtained.

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