Publications by authors named "A J Hough"
Article Synopsis
- - Children born via cesarean delivery have a greater risk of various health issues compared to those born vaginally, but the exact reasons are still not fully understood.
- - A meta-analysis involving over 12,000 participants found six specific DNA methylation markers in newborns linked to cesarean delivery, but these markers did not persist into childhood.
- - The study indicates that cesarean delivery affects certain blood cell proportions at birth, but further research is necessary to understand its long-term impacts on child health.
Prioritisation of early pregnancy risk factors for stillbirth: An international multistakeholder modified e-Delphi consensus study.
Eur J Obstet Gynecol Reprod Biol
November 2024
Objective: To identify and prioritise early pregnancy risk factors for stillbirth to inform prognostic factor and model research.
Study Design: We used a modified e-Delphi method and consultation meeting to achieve consensus. Risk factors for early, late and stillbirth at any gestation identified from an umbrella review of risk factors for stillbirth were entered into a two-stage online Delphi survey with an international group of stakeholders made up of healthcare professionals and researchers.
Sexual and reproductive health clinical consultations: preconception care.
BMJ Sex Reprod Health
October 2024
Article Synopsis
- * This study aimed to find genetic variations (SNPs and CNVs) affecting how children metabolize phthalates by analyzing data from 1,044 children in the HELIX cohort.
- * Significant genetic loci associated with phthalate metabolism were identified, along with genes related to detoxification processes and renal excretion, suggesting a strong genetic component influencing how these compounds are processed in the body.
Background: The 2017 American College of Cardiology/American Heart Association blood pressure guideline recommends chlorthalidone as the preferred thiazide diuretic. We aimed to better understand thiazide prescribing patterns within the US Department of Veterans Affairs (VA).
Methods: A retrospective analysis was conducted of patients with a prescription for hydrochlorothiazide (HCTZ), chlorthalidone, indapamide, or any combination products containing these from January 1, 2016, to January 21, 2022.