Publications by authors named "A J Horn"
Background And Purpose: Endovascular thrombectomy (EVT) is the standard for acute ischemic stroke from large vessel occlusion, but post-EVT functional independence varies. Brain atrophy, linked to higher cerebrospinal fluid volume (CSFV), may affect outcomes. Baseline CSFV could predict EVT benefit by assessing brain health.
View Article and Find Full Text PDFDeep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as the primary target, recently, stimulation of the subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not been studied in depth.
View Article and Find Full Text PDFCarboxypeptidase is a Zn-dependent protease that specifically recognises and hydrolyses peptides with a hydrophobic side chain at the C-terminal residue. According to hydrolysis mechanisms proposed in the literature, catalysis requires a water molecule to be close to the Zn ion so as to be activated as a nucleophile. Among small molecules that resemble the slowly hydrolysed Gly-Tyr peptide, which have been previously designed as inhibitors and characterised structurally, a variant with the terminal amino acid in a D-configuration has been the most effective.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on identifying risk factors for subtalar fusion (STF) after open reduction internal fixation (ORIF) of calcaneal fractures, finding that certain demographics and medical issues can influence outcomes.
- Both alcohol and drug abuse, depression, obesity, and tobacco use are associated with an increased likelihood of undergoing STF within five years following surgery.
- The analysis utilized a national claims database over nearly 12 years, revealing no significant differences in reimbursement rates or basic demographics between patients who required STF and those who did not.