Publications by authors named "A J Hoogendijk"
Article Synopsis
- The immune response against tumors relies on various immune cells that recognize cancer cells through different receptors, but tumors can evade detection by manipulating these interactions.
- The study highlights the role of neolacto-series glycosphingolipids (nsGSLs), linked to the enzyme B3GNT5, in enabling tumors to escape immune recognition, particularly focusing on how the loss of signal peptide peptidase like 3 (SPPL3) leads to increased nsGSL levels that impair CD8 T cell activation.
- Findings reveal that tumor cells deficient in SPPL3 are less targeted by neutrophils and NK cells, and the interaction dynamics—particularly through nsGSL expression—can influence immune cell activation and effectiveness, suggesting potential
Introduction: Neutrophils play a dichotomous role in community-acquired pneumonia (CAP), providing protection and potentially causing damage. Existing research on neutrophil function in CAP relies on animal studies, leaving a gap in patient-centered investigations.
Methods: We used mass spectrometry to characterize the neutrophil proteome of moderately ill CAP patients at general ward admission and related the proteome to controls and clinical outcomes.
Background: The vascular endothelial cell (EC) monolayer plays a crucial part in maintaining hemostasis. An extensive array of G protein-coupled receptors allows ECs to dynamically act on key hemostatic stimuli such as thrombin and histamine. The impact of these individual stimuli on EC signal transduction has been the subject of various studies, but insight into discordant and concordant EC signaling between different G protein-coupled receptors remains limited.
View Article and Find Full Text PDFBackground: Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management.
Aims: We explored associations between plasma protein levels and fever- and infection-related complications in 26 AML patients during chemotherapy-induced neutropenia.
Background: Preterm infants, especially those born small for gestational age (SGA), are at risk of short-term and long-term health complications. Characterization of changes in circulating proteins postnatally in preterm infants may provide valuable fundamental insights into this population. Here, we investigated postnatal developmental patterns in preterm infants and explored protein signatures that deviate between SGA infants and appropriate for gestational age (AGA) infants using a mass spectrometry (MS)-based proteomics workflow.
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