Publications by authors named "A J Grisold"
Article Synopsis
- The study examined antibiotic resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in Europe, focusing on changes influenced by aging populations, migrations, and climate change over the last three years.
- Researchers compared hospital and community isolates to analyze resistance mechanisms, trends, and types of carbapenemases and plasmids, using methods like disk diffusion and PCR.
- Results showed high resistance rates to common antibiotics, with OXA-48 being the predominant carbapenemase found in the majority of isolates, indicating a similar trend to neighboring countries.
Objectives: This study aimed to evaluate and compare the performance of different assays for antimicrobial susceptibility testing (AST) and minimum inhibitory concentration (MIC) determination for reserve antibiotics in carbapenem-resistant Enterobacterales (CREs), (CRPAs), and (CRABs).
Methods: An analysis was conducted on 100 consecutive isolates: 50 CREs, 35 CRPAs, and 15 CRABs. Sensititre broth microdilution was used as a reference standard to evaluate the performance of VITEK 2 card AST-XN24 (bioMérieux), the respective gradient tests (bioMérieux), and UMIC colistin broth microdilution test strips (Bruker Daltonics).
Carbapenem resistant (CRE) and carbapenemase producing Enterobacterales (CPE) in particular, represent a major threat for healthcare systems worldwide. Rapid, reliable, and easy to perform assays are required to enable targeted and effective therapy. MALDI-TOF MS based carbapenemase diagnostics has potential advantages over molecular and phenotypic sensitivity tests, especially in terms of time to result.
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- Biallelic SUFU variants are linked to severe conditions like Joubert syndrome, while heterozygous truncating variants are associated with milder issues such as developmental delay and ocular motor apraxia, though limited cases have been studied. !* -
- The study examined nine individuals across three families with truncating SUFU variants, detailing their neuroimaging and developmental assessments to explore the phenotypic expression of these variants. !* -
- Findings revealed a wide range of symptoms including motor developmental delays and subtle neuroimaging abnormalities, indicating that SUFU haploinsufficiency presents with varying severity, even among family members. !*
Multidrug-resistant (MDR) bacteria of the utmost importance are extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Enterobacterales (CRE), carbapenem-resistant (CRAB), carbapenem-resistant (CRPA), methicillin-resistant (MRSA) and vancomycin-resistant spp. (VRE). In this study, an evaluation of MDR bacteria in surgical intensive care units in a tertiary referral hospital was conducted.
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