Biomarkers.

Background: Neurofilament light chain (NfL) is a fluid biomarker of axonal damage reported to be elevated in cases with dementia, and particularly in FTD. In this study we evaluate the performance of a recently developed NfL assay to be analyzed through the Lumipulse chemiluminescent platform, which is frequently available in clinical settings for the study of AD core biomarkers.

Method: We evaluated CSF NfL levels using the Lumipulse G600II platform (Fujirebio, Iberia) in 70 cases, including 33 patients with AD (supported by CSF biomarkers consistent with an A+T+(N)+ classification scheme), 26 with confirmed FTD (typical phenotype and CSF with a A-T- profile), and 11 controls.

Biomarkers.

Background: Recent reports support the use of plasma biomarkers of neurodegeneration and neuroinflammation, as determined through ultrasensitive single molecular arrays (SIMOA), to screen and diagnose patients with dementia. However, their translation to clinical settings requires further studies.

Methods: We evaluated plasma samples from 186 individuals including 72 patients with AD (supported by CSF biomarkers consistent with an A+T+N+ classification scheme), 44 with confirmed FTD, 48 cognitively intact nonagenarians, and 22 controls (ages 40-83 years).

Extended reality as a modality to train non-technical skills in healthcare: A scoping review.

The need to train non-technical skills (NTS) has seen a growing emphasis in recent literature, as they have been associated with improved patient outcomes. NTS training often utilizes live simulations where healthcare workers can practice these skills, but simulations like this can be expensive and resource intensive to run. Training technical skills using extended reality tools (e.

Analysis of Metal-Organic Framework and Polyamide Interfaces in Membranes for Water Treatment and Antibacterial Applications.

Integrating biocidal nanoparticles (NPs) into polyamide (PA) membranes shows promise for enhancing resistance to biofouling. Incorporating techniques can tailor thin-film nanocomposite (TFN) membranes for specific water purification applications. In this study, silver-based metal-organic framework Ag-MOFs (using silver nitrate and 1,3,5-benzentricarboxylic acid as precursors) are incorporated into PA membranes via three different methods: i) incorporation, ii) dip-coating, and iii) in situ ultrasonic techniques.

Light-sensitive Ca signaling in the mammalian choroid.

The choroid is the thin, vasculature-filled layer of the eye situated between the sclera and the retina, where it serves the metabolic needs of the light-sensing photoreceptors in the retina. Illumination of the interior surface of the back of the eye (fundus) is a critical regulator of subretinal fluid homeostasis, which determines the overall shape of the eye, but it is also important for choroidal perfusion. Noted for having some of the highest blood flow rates in the body, the choroidal vasculature has been reported to lack intrinsic, intravascular pressure-induced (myogenic) autoregulatory mechanisms.