An Analysis of the Influence of a Patient's Sex on Quality of Life in Liver and Kidney Transplantation.

Background: Renal and liver transplantation influences the quality of life of the patients who undergo these procedures. Therefore, the aim of the present study was to analyze possible differences in liver and kidney transplantation in relation to the patient's sex and to determine their impact on quality of life.

Methodology: An observational study was carried out with 147 patients with liver ( = 70) and kidney ( = 77) failure on the transplantation waiting list.

Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation.

Intestinal smooth muscle differentiation is a complex physico-biological process involving several different pathways. Here, we investigate the properties of Ca waves in the developing intestinal mesenchyme using GCamp6f expressing mouse embryos and investigate their relationship with smooth muscle differentiation. We find that Ca waves are absent in the pre-differentiation mesenchyme and start propagating immediately following α-SMA expression.

Piezo2 channels and tactile pain: an intriguing voltage connection.

This scientific commentary refers to ‘Piezo2 voltage-block regulates mechanical pain sensitivity’ by Sánchez-Carranza (https://doi.org/10.1093/brain/awae227).

Proper Frequency of Perinatal Retinal Waves Is Essential for the Precise Wiring of Visual Axons in Nonimage-Forming Nuclei.

The development of the visual system is a complex and multistep process characterized by the precise wiring of retinal ganglion cell (RGC) axon terminals with their corresponding neurons in the visual nuclei of the brain. Upon reaching primary image-forming nuclei (IFN), such as the superior colliculus and the lateral geniculate nucleus, RGC axons undergo extensive arborization that refines over the first few postnatal weeks. The molecular mechanisms driving this activity-dependent remodeling process, which is influenced by waves of spontaneous activity in the developing retina, are still not well understood.