Publications by authors named "A J Ghio"
Article Synopsis
- The study investigates the effect of extreme heat on respiratory hospitalizations among older adults (65+) across the 120 largest US cities from 2000 to 2017, highlighting a gap in understanding how heat impacts respiratory health in different demographic groups.* -
- Analysis revealed over 3 million respiratory hospitalizations, with high temperatures leading to a cumulative 1.2% increase in all-cause respiratory disease hospitalizations, significantly driven by respiratory infections and chronic respiratory conditions.* -
- Results showed that the heat index provided a stronger correlation with increased hospitalizations compared to temperature alone, and the risk of heat-related respiratory issues varied notably across different geographic locations.*
Neutrophil elastase activates macrophage calpain as a mechanism for phagocytic failure.
Am J Physiol Lung Cell Mol Physiol
January 2025
Neutrophil elastase (NE), elevated in the cystic fibrosis (CF) airway, causes macrophage phagocytic failure. We previously reported that NE increases the release of protease calcium ion-dependent papain-like cysteine protease-2 (Calpain-2) in macrophages. We hypothesized that NE mediates macrophage failure through activation of Calpains.
View Article and Find Full Text PDFThe hypercoagulable state associated with sickle cell disease (SCD) can be challenging for apheresis procedures. Among 62 single-needle red cell exchanges (SN-RCEs) performed over a 15-month period, 4 patients experienced 6 hemolytic events with a discolored plasma layer, elevated plasma/RBC interface in the centrifuge, and accompanying alarms of "Cells were detected in plasma line from centrifuge" or "AIM system detected RBC at top of connector." The hemolysis originated from the apheresis instrument because samples from the apheresis belt but not the patients' peripheral blood were positive for hemolysis.
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