Publications by authors named "A J Gentles"
Endometriosis is an inflammatory chronic condition associated with nociceptive, neuropathic, and nociplastic pain. Central sensitization (CS) is the primary nociplastic pain mechanism. However, there are currently no standardized methods for detecting CS or nociplastic pain.
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- Immuno-oncology is revolutionizing cancer treatment, but most patients do not see long-lasting benefits, indicating a need for further advancements in the field.
- Computational immuno-oncology combines biomedical data science with oncology and immunology to enhance the development of effective immunotherapy treatments from research to clinical application.
- The review highlights 10 key challenges and opportunities in computational immuno-oncology, stressing the need for strong computational methods and teamwork to adapt to rapid changes in clinical demands and technology.
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- The study evaluates various deconvolution methods that estimate immune cell levels in tumor samples based on gene expression data during a DREAM Challenge.
- While many established methods perform adequately for most immune cell types, they struggle with accurately assessing all states of functional CD8+ T cells.
- Community-contributed methods, particularly a deep learning approach, have shown promising results and could enhance the development of deconvolution techniques, especially in identifying functional CD4+ T cell states.
Hematopoietic multipotent progenitors (MPPs) regulate blood cell production to appropriately meet the biological demands of the human body. Human MPPs remain ill-defined whereas mouse MPPs have been well characterized with distinct immunophenotypes and lineage potencies. Using multiomic single cell analyses and complementary functional assays, we identified new human MPPs and oligopotent progenitor populations within Lin-CD34+CD38dim/lo adult bone marrow with distinct biomolecular and functional properties.
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