Publications by authors named "A J Geerards"
Article Synopsis
- High myopia is increasingly common globally, leading to a rise in vision-related issues; however, research on its complications in Europeans is limited.
- The study aimed to evaluate the prevalence of myopic macular features among Europeans with high myopia, involving 626 patients from the Dutch Myopia Study and the Rotterdam Study.
- Results showed that 25.9% had myopic macular degeneration, which was more prevalent in older individuals, those with lower spherical equivalent refractive errors, and greater axial length.
Article Synopsis
- The study investigates the impact of the GJD2 gene on myopia (nearsightedness) across different age groups, looking specifically at its relationship with refractive error and eye measurements.
- Using data from three major population studies, researchers measured various eye metrics (like spherical equivalent and axial length) in relation to different GJD2 genotypes and assessed lifestyle factors' effects.
- Results showed that individuals with two risk alleles had worse eye measurements, indicating a dose-response effect that begins in early childhood, suggesting that this gene could significantly influence the development of myopia.
Article Synopsis
- * A large-scale study involving nearly 4,700 keratoconus cases and over 116,000 controls identified 36 genomic regions linked to the disease, highlighting issues with collagen integrity and cell differentiation as crucial factors.
- * The findings reveal shared genetic mechanisms with other corneal diseases and suggest that the identified genetic variants account for 12.5% of keratoconus's genetic risk, paving the way for future diagnostic tests to assess susceptibility.
Objective: Comparison of conventional Penetrating Keratoplasty (PKP), posterior mushroom PKP and Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) regarding overall graft survival of primary corneal transplants for Fuchs´ endothelial dystrophy (FED), best spectacle-corrected visual acuity (BSCVA) and astigmatism.
Methods: Single centre study using prospectively collected data from the national database for follow-up of corneal transplants. Main outcome parameters: 10 years graft survival, astigmatism at 24 months, pre- and post-operative BSCVA.
Importance: Myopia (ie, nearsightedness) is becoming the most common eye disorder to cause blindness in younger persons in many parts of the world. Visual impairment due to myopia is associated with structural changes of the retina and the globe because of elongation of the eye axis. How axial length-a sum of the anterior chamber depth, lens thickness, and vitreous chamber depth-and myopia relate to the development of visual impairment over time is unknown.
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