Impact of persistent pulmonary hypertension on cerebral oxygenation in infants with neonatal encephalopathy.

Background: Persistent pulmonary hypertension of the newborn (PPHN) affects systemic oxygenation and may worsen brain injury in infants with neonatal encephalopathy (NE). Evidence suggests that higher cerebral regional oxygenation (crSO) indicates derangement in cerebral autoregulation, energy metabolism, and blood flow following NE. Our aim was to evaluate the impact of PPHN on crSO, in infants with NE treated with therapeutic hypothermia (TH).

Machine learning models of cerebral oxygenation (rcSO) for brain injury detection in neonates with hypoxic-ischaemic encephalopathy.

The present study was designed to test the potential utility of regional cerebral oxygen saturation (rcSO) in detecting term infants with brain injury. The study also examined whether quantitative rcSO features are associated with grade of hypoxic ischaemic encephalopathy (HIE). We analysed 58 term infants with HIE (>36 weeks of gestational age) enrolled in a prospective observational study.

Deliberate and Self-Conscious Adaptation of Eye-Contact by Autistic Adults.

Eye gaze is widely recognised as an important element in managing social interactions, receiving information from others and communicating information about ourselves. Atypical eye gaze is one of the characteristic hallmarks of autism. Experimental research has contributed significantly to our knowledge of eye-gaze in autism, however, there is a lack of research exploring how autistic individuals describe and understand the phenomenological experience of eye-gaze and eye-contact.

Quantitative EEG and prediction of outcome in neonatal encephalopathy: a review.

Electroencephalogram (EEG) is an important biomarker for neonatal encephalopathy (NE) and has significant predictive value for brain injury and neurodevelopmental outcomes. Quantitative analysis of EEG involves the representation of complex EEG data in an objective, reproducible and scalable manner. Quantitative EEG (qEEG) can be derived from both a limited channel EEG (as available during amplitude integrated EEG) and multi-channel conventional EEG.

Management of neonatal hypoglycaemia in a tertiary maternity unit-A multidisciplinary quality improvement project.

Aim: Improved identification and treatment of infants at risk of hypoglycaemia using evidence-based guidelines.

Methods: Design: Prospective, multidisciplinary quality improvement project (QIP).

Setting: Tertiary maternity hospital, Dublin (2016-2023).