Publications by authors named "A J Garcia-Garcia"
Article Synopsis
- Exposure to high-energy diets during fetal development can increase the risk of type 2 diabetes in offspring due to glucose imbalance linked to specific lipids.
- Research focuses on C24:0 ceramide, a lipid found in increased amounts in offspring of rats on high-energy diets and obese-T2DM individuals, which disrupts glucose balance and triggers metabolic issues.
- C24:0 ceramide impairs energy processing in fat and liver cells by promoting harmful conditions in mitochondria and stressing the endoplasmic reticulum, contributing to overall glucose imbalance and fat accumulation.
Oral squamous cell carcinoma (OSCC) poses significant health risks with increasing incidence and mortality rates. In this context, there is an urgent need to explore novel biomarkers to enhance therapeutic strategies and improve survival. Understanding apoptotic evasion in cancer pathogenesis, this pioneering study aims to investigate the correlation between a pro-apoptotic protein Smac/DIABLO and patient prognosis within the OSCC cohort.
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