Optimizing oilseed rape growth: Exploring the effect of foliar biostimulants on the interplay among metabolism, phenology, and yield.

The current agricultural system is in search of new strategies to achieve a more sustainable production while keeping or even increasing crop yield and quality. In this scenario, the application of biostimulants constitutes a potent solution. In the current study, the impact of a blue-green microalgal extract (MB) and a pig tissue hydrolysate (PTH) on rapeseed plants' development was characterized.

HepG2 PMM2-CDG knockout model: A versatile platform for variant and therapeutic evaluation.

Phosphomannomutase 2 deficiency (PMM2-CDG), the most frequent congenital disorder of glycosylation, is an autosomal recessive disease caused by biallelic pathogenic variants in the PMM2 gene. There is no cure for this multisystemic syndrome. Some of the therapeutic approaches that are currently in development include mannose-1-phosphate replacement therapy, drug repurposing, and the use of small chemical molecules to correct folding defects.

Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms.

Ferroptosis is a form of regulated cell death that can be modulated by small molecules and has the potential for the development of therapeutics for oncology. Although excessive lipid peroxidation is the defining hallmark of ferroptosis, DNA damage may also play a significant role. In this study, a potential mechanistic role for MIF in homologous recombination (HR) DNA repair is identified.

Phenotypic Features in a New 12q21 Deletion and Its Association With Cardiofaciocutaneous Syndrome.

Arriving at a diagnosis in children with developmental delay, cognitive impairments, and multiple physical abnormalities at birth can be very taxing due to many differential diagnoses and etiologies. Of the plethora of conditions that are seen among infants, chromosomal disorders, in particular, present with challenges in diagnosis and devastating consequences. In recent times, the advent of chromosomal microarray techniques has made it possible to easily identify chromosomal deletions and arrive at a diagnosis.