[Characteristics of the set-up of the lymphocyte blast transformation reaction using whole blood].

The authors analyze the specific features of the technique of lymphocyte blastogenesis test (LBGT) with whole blood and of interpreting its results in examinations of healthy donors, patients with hypogammaglobulinemia, chronic bronchitis or pneumonia, and bronchial asthma. The suggested LBGT variant is a sensitive and reproducible technique fit for assessing the immunity status, making use of small volumes (up to 0.1 ml) of the blood; it is recommended for clinical examinations and mass immunologic screenings.

[Effect of human regulatory myelopeptides on the elaboration of a factor inhibiting leukocyte migration].

Some properties of the regulatory peptides from human bone marrow have been investigated. It has been determined that the activity of the regulatory peptides was different in healthy donors and patients with agammaglobulinemia and paraproteinemia.

Early adventures in drug metabolism: 4. Diphenylhydantoin (phenytoin).

This series comes to a close with a discussion of problems related to phenytoin metabolites, their discovery and role in the toxicity of this drug. More particularly, it looks at the influence of the p-hydroxyphenyl metabolite of phenytoin (HPPH) on the metabolic disposition of the parent compound, and the relationship of the dihydrodiol metabolite to the putative presence of arene oxides. The question of pro-drugs is examined, including factors that may influence any decision to market the drug.

Early adventures in drug metabolism. 3. Chloramphenicol.

The saga of our early experiences with drug metabolism studies in the Parke-Davis Research Laboratories continues with a brief resume of the behavior of chloramphenicol under unusual clinical conditions and a consideration of the toxic effects of this drug and its metabolites in laboratory animals and in humans. The dose-related reversible effects of chloramphenicol upon the ferrokinetic pattern and cellular respiration are clearly separated from its nonreversible effects on the bone marrow cells of susceptible individuals. A number of possible research approaches are suggested for the exploration of these problems.