Publications by authors named "A J Freemont"
Screening of postmortem blood and urine samples is used to identify compounds that may have contributed to an individual's death. Toxicologically significant compounds detected by the screen are then quantitated in blood to determine their likely effect upon death. In most laboratories, this is a two-step process.
View Article and Find Full Text PDFObjective: Biomarkers in osteoarthritis (OA) could serve as objective clinical indicators for various disease parameters, and act as surrogate endpoints in clinical trials for disease-modifying drugs. The aim of this systematic review was to produce a comprehensive list of candidate molecular biomarkers for knee OA after the 2013 ESCEO review and discern whether any have been studied in sufficient detail for use in clinical settings.
Design: MEDLINE and Embase databases were searched between August 2013 and May 2018 using the keywords "knee osteoarthritis," "osteoarthritis," and "biomarker.
A 51-year old presented with a 6-month history of increasing pelvic/lower back pain with nocturnal waking and episodes of anorexia and vomiting. Examination revealed right torticollis and Horner's syndrome, and a large abdominal mass arising from the pelvis. Magnetic resonance and positron emission tomography imaging revealed (A) a 14 cm heterogeneous enhancing mass, abutting the left kidney with standardised uptake value max = 2.
View Article and Find Full Text PDFObjectives: We sought to evaluate diagnostic accuracy of a high-sensitivity cardiac troponin I (hs-cTnI) assay for acute coronary syndromes (ACS) in the emergency department (ED). The assay has high precision at low concentrations and can detect cTnI in 96.8% of healthy individuals.
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed a new type of PEG-based nanocomposite hydrogels with customizable mechanical strength through unique chemical reactions involving diglycidyl ethers and carboxylate ions.
- The hydrogels are formed using crosslinked polyacid nanogels, which effectively enhance the mechanical properties of the PEG matrix, resulting in a compressive PEG-based hydrogel with impressive strength (24.2 MPa) and high strain (over 98%).
- These hydrogels show potential for medical applications, such as replacing intervertebral discs or articular cartilages, with tests indicating that they are non-toxic to human cells after eight days of culture.