Publications by authors named "A J El Haj"
The ability to control the growth and orientation of neurites over long distances has significant implications for regenerative therapies and the development of physiologically relevant brain tissue models. In this study, the forces generated on magnetic nanoparticles internalised within intracellular endosomes are used to direct the orientation of neuronal outgrowth in cell cultures. Following differentiation, neurite orientation was observed after 3 days application of magnetic forces to human neuroblastoma (SH-SY5Y) cells, and after 4 days application to rat cortical primary neurons.
View Article and Find Full Text PDFPurpose: The development of brain metastases (BM) can significantly increase the psycho-oncological burden in cancer patients, requiring timely intervention. In addition, this aspect may negatively affect the course of the disease and treatment outcome. However, screening for psycho-oncological burden is often overlooked in clinical routine.
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- Patchy data on litter decomposition in wetlands limits understanding of carbon storage, prompting a global study involving over 180 wetlands across multiple countries and climates.
- The study found that freshwater wetlands and tidal marshes had more organic matter remaining after decay, indicating better potential for carbon preservation in these areas.
- Elevated temperatures positively affect the decomposition of resistant organic matter, with projections suggesting an increase in decay rates by 2050; however, the impact varies by ecosystem type and highlights the need to recognize both local and global factors influencing carbon storage.
Article Synopsis
- - Magnetic nanoparticles (MNPs) are tiny particles (1 to 100 nanometers) made from magnetic materials, possessing unique properties that differ from larger forms; they are increasingly used in various fields such as medicine and technology.
- - Their small size and magnetic behavior allow for manipulation with external magnetic fields, making them useful for targeted medical applications like drug delivery and imaging, while also being explored for environmental and energy-related uses.
- - Despite the growing applications of MNPs, there are important concerns about their safety, such as potential toxicity and how they interact with cells, which is becoming a focus of both research and clinical studies.
Background: The vitamin K-dependent coagulation factor protein Z (PZ), encoded by the PROZ gene, is canonically considered to have anticoagulant effects through negative regulation of factor Xa. Paradoxically, higher circulating PZ concentrations have repeatedly been associated with an elevated risk of acute ischemic stroke.
Objectives: We performed a large-scale genetic association study to examine the relationship between germline genetic variants in PROZ and the risk of ischemic stroke.