Publications by authors named "A J Dwork"
Light-sheet fluorescence microscopy (LSFM) is a widely used technique for imaging cleared tissue and living samples. However, high-performance LSFM systems are typically expensive and not easily scalable. Here we introduce a low-cost, scalable and versatile LSFM framework, which we named 'projected light-sheet microscopy' (pLSM), with high imaging performance and small device and computational footprints.
View Article and Find Full Text PDFBackground: Infectious diseases can contribute to substance abuse. Here, a fatal case of borreliosis and substance abuse is reported. This patient had a history of multiple tick bites and increasing multisystem symptoms, yet diagnosis and treatment were delayed.
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- Mitochondrial oxidative phosphorylation (OxPhos) is crucial for brain function, and its defects are linked to various brain disorders, highlighting the importance of understanding brain energy dynamics.
- Researchers created a voxel-based analysis method to study mitochondrial characteristics across human brain tissue, revealing variations in mitochondrial traits based on brain structure and cell types.
- The findings include a greater concentration and optimized function of mitochondria in grey matter compared to white matter, leading to the development of a MitoBrainMap that connects mitochondrial features to overall brain health and potential neuropsychiatric conditions.
Article Synopsis
- Mitochondrial oxidative phosphorylation (OxPhos) is crucial for brain activity and defects in mitochondria are linked to neurodegenerative and psychiatric disorders, highlighting the need to understand brain energy dynamics.
- Researchers created a method to analyze a human brain section in 703 small volumes (voxels) to study mitochondrial characteristics like enzyme activities, DNA, and respiratory capacity across different brain regions.
- The findings reveal that grey matter has more mitochondria than white matter, which are more efficient at energy production, leading to the development of a MitoBrainMap that connects these mitochondrial distributions to brain function and potential disorders.