Publications by authors named "A J Dorn"
Article Synopsis
- The text outlines the development of a plug-and-play adaptive optics module for commercial microscopes that uses a deformable phase plate to improve image quality through aberration correction.
- By estimating aberration profiles at multiple points and stitching corrected images together, the system aims to create high-quality full-field images.
- An empirical method is introduced to optimize measurement time and correction quality by aligning the field segment size with the isoplanatic patch, enhancing overall performance in real-world applications.
Facioscapulohumeral muscular dystrophy (FSHD) is caused by sporadic misexpression of the transcription factor double homeobox 4 (DUX4) in skeletal muscles. So far, monolayer cultures and animal models have been used to study the FSHD disease mechanism and for FSHD therapy development, but these models do not fully recapitulate the disease and there is a lack of knowledge on how DUX4 misexpression leads to skeletal muscle dysfunction. To overcome these barriers, we have developed a three-dimensional tissue engineered skeletal muscle (3D-TESM) model by generating genetically matched myogenic progenitors (MPs) from human induced pluripotent stem cells of three mosaic FSHD patients.
View Article and Find Full Text PDFSerine 129 can be phosphorylated in pathological inclusions formed by the intrinsically disordered protein human α-synuclein (AS), a key player in Parkinson's disease and other synucleinopathies. Here, molecular simulations provide insight into the structural ensemble of phosphorylated AS. The simulations allow us to suggest that phosphorylation significantly impacts the structural content of the physiological AS conformational ensemble in aqueous solution, as the phosphate group is mostly solvated.
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