Publications by authors named "A J Distefano"
L-carnosine (Car) is an endogenous dipeptide with significant potential in drug discovery for neurodegenerative diseases, while TAT1, a small arginine-rich peptide derived from the HIV-1 trans-activator protein (TAT), is known to stimulate proteasome activity. In this study, three isomeric peptides were synthesised by incorporating the Car moiety at the N-terminus, C-terminus, or central position of the TAT1 sequence. To differentiate these isomers, high-resolution and energy-resolved CID MS/MS experiments were conducted.
View Article and Find Full Text PDFBackground: Micro-RNAs (miRNAs) have been reported to play an important role during orthodontic tooth movement (OTM) through the regulation of periodontal soft and hard tissue homeostasis and functions. The aim of the present study was to assess the effects of miRNAs on OTM and to evaluate possible predictors that influenced the overall OTM amount at a 3-month follow-up.
Methods: Through a split-mouth design, 21 healthy patients (mean age 13.
Curcumin (Cur), the primary curcuminoid found in L., has garnered significant attention for its potential anti-inflammatory and antibacterial properties. However, its hydrophobic nature significantly limits its bioavailability.
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- Tobacco smoking is the leading cause of preventable deaths worldwide, prompting research into its effects on microglial cells, which are vital for brain health.
- The study reveals that cigarette smoke significantly damages these cells by increasing oxidative stress and inflammation, while heated tobacco products (HTPs) showed less harmful effects.
- The findings suggest that switching to HTPs may reduce some risks associated with traditional smoking, offering a possible strategy for harm reduction in neurodegenerative diseases.
Fish oil, renowned for its high content of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has gained considerable attention for its potential health benefits. EPA and DHA exhibit anti-inflammatory effects by promoting the production of specialized pro-resolving mediators (SPMs), such as resolvins and protectins. Fish oil has been studied for its potential to reduce bronchial inflammation, a key feature of respiratory conditions like asthma and COPD.
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