Ruthenium, copper and ruthenium-copper complexes of an unsymmetrical phosphino pyridyl 1,8-naphthyridine PNNN ligand.

A new unsymmetrical dinucleating phosphino pyridyl 1,8-naphthyridine ligand PNNN is reported. Reaction with CuCl gave the dicopper complex [Cu(μ-Cl)(PNNN)] (1). In contrast, complexation of [RuCl(cymene)] yielded a monometallic species [RuCl(cymene)(PNNN)]Cl ([2]Cl) in which the Ru is bound to the κ-N,N, rather than κ-P,N, binding pocket.

Expedient Decagram-Scale Synthesis of Robust Organic Cages That Bind Sulfate Strongly and Selectively in Water.

Selective anion recognition remains a key challenge in supramolecular chemistry: only a very small number of systems that can function in water are known, and these nearly always preferentially bind hydrophobic anions. In this work, we report three robust hexa-cationic cages that can be prepared on scales up to 14 g in two simple and high-yielding steps from commercially available materials. One of these cages displays unusually strong sulfate binding in water ( = 12,000 M), and demonstrates high selectivity for this anion over HPO/HPO in DMSO/buffer mixtures.

The Effect of Neoadjuvant Systemic Therapy on Surgical Outcomes After Lymph Node Dissections for Stage III Melanoma; An Australian Cohort.

Background: Neoadjuvant systemic therapy (NAST) for patients with stage III melanoma achieves high major pathologic response rates and high recurrence-free survival rates. This study aimed to determine how NAST with targeted therapies (TTs) and immune checkpoint inhibitors (ICIs) influences surgical outcomes after lymph node dissection in terms of complications, morbidity, and textbook outcomes.

Methods: Patients who underwent a lymph node dissection after either NAST in a clinical trial or upfront surgery for stage III melanoma between 2014 and 2022 were identified from an institutional research database.

Utilising a Proton-Responsive 1,8-Naphthyridine Ligand for the Synthesis of Bimetallic Palladium and Platinum Complexes.

We present four proton-responsive palladium and platinum complexes, [MCl ( PONNHO)] (M=Pd, Pt; R= Pr, Bu) synthesised by complexation of PdCl or PtCl (COD) with the 1,8-naphthyridine ligand PONNHO. Deprotonation of [MCl ( PONNHO)] switches ligand coordination from mono- to dinucleating, offering a synthetic pathway to bimetallic Pd and Pt complexes [M Cl ( PONNO) ]. Two-electron reduction gives planar M -M complexes [M ( PONNO) ] (M=Pd, Pt) containing a metal-metal bond.