Publications by authors named "A J Chura"
Enteroendocrine cells (EECs) are crucial for sensing ingested nutrients and regulating feeding behavior. How gut microbiota regulate the nutrient-sensing EEC activity is unclear. Our transcriptomic analysis demonstrates that commensal microbiota colonization significantly increases the expression of many genes associated with mitochondrial function.
View Article and Find Full Text PDFThe enteroendocrine cells (EECs) in the intestine are crucial for sensing ingested nutrients and regulating feeding behavior. The means by which gut microbiota regulates the nutrient-sensing EEC activity is unclear. Our transcriptomic analysis of the EECs from germ-free (GF) and conventionalized (CV) zebrafish revealed that commensal microbiota colonization significantly increased the expression of many genes that are associated with mitochondrial function.
View Article and Find Full Text PDFAssessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children.
J Allergy Clin Immunol Pract
April 2023
Article Synopsis
- A study examined the difference in atopic comorbidities, such as asthma and allergic rhinitis, between Black and White children with food allergies, finding that Black children have a higher risk.
- Researchers used a comprehensive area deprivation index (ADI) to assess the influence of socioeconomic status on these health disparities.
- The results indicated that while neighborhood socioeconomic deprivation is linked to asthma and allergic rhinitis, Black children still faced a greater risk for asthma even after accounting for SES factors.
Background: Despite major differences in health profiles and rates of health care utilization between African American and White children with food allergy (FA), the detailed phenotypic variables that can potentially impact these outcomes have not been thoroughly studied.
Objective: We aimed to characterize phenotypic differences such as allergies to different foods and allergic comorbidities between African American and White children with FA enrolled in the Food Allergy Outcomes Related to White and African American Racial Differences study.
Methods: Our active, prospective, multicenter cohort study is currently enrolling African American and White children aged 0 to 12 years diagnosed with FA and followed by allergy/immunology clinics at 4 urban tertiary centers in the United States.