Publications by authors named "A J Chitkara"

Article Synopsis
  • A study analyzed cancer drug approvals from 2011 to 2023, focusing on whether new drugs are introduced as combination therapies or as stand-alone treatments (monotherapies).
  • Of the 292 drug approvals evaluated, 66.1% were monotherapies and 33.9% were combinations; combinations had higher approval rates and overall survival benefits but were less likely to feature novel drugs.
  • Despite some advantages in response rates for combination therapies, the overall clinical benefits for both drug types were modest, suggesting a need for simpler, more patient-centered cancer treatment approaches.
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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily a respiratory virus causing coronavirus disease 2019 (COVID-19) pneumonia, induces a hypercoagulable state. Previous studies comparing the prevalence of venous thromboembolism (VTE) in patients with COVID-19 pneumonia and those with influenza pneumonia revealed a higher risk of pulmonary embolism (PE) and deep vein thrombosis (DVT) associated with COVID-19 pneumonia. However, these studies have not adequately accounted for the severity and acuity of the presenting viral pneumonia.

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Chimeric Antigen Receptor T-cell (CAR-T) therapy uses genetically engineered T-cells with specific binding sites. This therapy allows for tumor specificity and durable treatment responses for patients with hematological malignancies. In this review, we study the risk of venous thromboembolism (VTE) associated with CAR-T therapy.

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Human immunodeficiency virus (HIV) infection weakens immunity. Monitoring the immune status of the patient has become an important aspect of evaluating the progression of the disease and informing follow-up after treatment. Estimation of CD4 counts is quite costly and requires expertise in flow cytometry.

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