Publications by authors named "A J Catchpole"
Blood transcriptional biomarkers of acute viral infections typically reflect type 1 interferon (IFN) signalling, but it is not known whether there are biological differences in their regulation that can be leveraged for distinct translational applications. We use high frequency sampling in the SARS-CoV-2 human challenge model to show induction of IFN-stimulated gene (ISG) expression with different temporal and cellular profiles. MX1 gene expression correlates with a rapid and transient wave of ISG expression across all cell types, which may precede PCR detection of replicative infection.
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- * Results showed that infected volunteers had significantly lower cognitive scores compared to their uninfected counterparts, particularly in tasks related to memory and executive function.
- * Despite the cognitive score differences, none of the volunteers reported ongoing subjective cognitive symptoms even after the study period of up to 360 days post-infection.
Background: Low-carbohydrate diets (LCD) are popular for weight loss but lack evidence about micronutrient sufficiency in real-life use. This study assessed the intake and biochemical status of selected micronutrients in people voluntarily following LCDs.
Methods: A cross-sectional study was conducted (2018-20) among 98 adults recruited as self-reporting either LCD (n = 49) or diets not restricting carbohydrates (controls; n = 49).
Article Synopsis
- The study investigates early cellular responses to SARS-CoV-2 infection using single-cell profiling in individuals with no prior immunity to the virus.
- Significant changes in cell types and immune responses were observed over time, indicating different patterns of infection severity, especially in nasopharyngeal regions.
- Key findings suggest that early interferon responses and specific immune cell behaviors, like high expression of HLA-DQA2, could be crucial in preventing sustained infections, while a novel computational tool, Cell2TCR, enhanced the analysis of T cell responses.