Publications by authors named "A J Capel"
Background: Proton therapy (PRT) is an innovative radiotherapeutic modality for the treatment of cancer with unique ballistic properties. The depth-dose distribution of a proton beam reduces exposure of healthy tissues to radiations, compared with photon-therapy (XRT). To date, only few indications for proton-therapy, like pediatric cancers, chordomas, or intra-ocular neoplasms, are reimbursed by Health systems.
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- Cerebrospinal fluid (CSF) is vital for brain health, providing nutrients, signaling, and removing toxins while supporting brain development and function.
- The study examined folate transport in CSF, focusing on key proteins that move folate from blood into CSF and then into brain cells, linking folate status to neurological conditions with ventricular enlargement.
- Findings indicate that various neurological conditions show distinct folate imbalances, suggesting that addressing these imbalances could help alleviate symptoms and deficits related to these conditions.
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- Skeletal muscle can release small particles (called SM-EVs) that help with muscle health and growth.
- Researchers compared these particles from young (about 24 years old) and older (about 69 years old) humans to see how aging affects them.
- They found that while the basic features of these particles didn't change much with age, older ones had more proteins linked to stress and possible damage, suggesting they play an important role in keeping muscles healthy as we get older.
Article Synopsis
- Elderly cancer patients, especially those over 70, can have trouble with thinking clearly, which affects their daily lives.
- This study looked at how well these patients could use a digital brain training app and whether they liked it.
- Out of 240 patients checked, about 145 were able to participate in the study to see if the app helped them improve their memory and thinking skills.
Background: Transarterial radioembolization in HCC for LT as downstaging/bridging has been increasing in recent years but some indication criteria are still unclear.
Methods: We conducted a systematic literature search of primary research publications conducted in PubMed, Scopus and ScienceDirect databases until November 2022. Relevant data about patient selection, HCC features and oncological outcomes after TARE for downstaging or bridging in LT were analyzed.